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中药化学

胡凯锋

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一、个人简介

胡凯锋,博士、教授、博士生导师、毕业于瑞士联邦苏黎世高等理工学院,获液态核磁共振技术博士,曾在美国NIH任研究助理,美国威斯康星大学任助理科学家。现任成都中医药大学教授,课题组长,四川省“特聘专家”;兼任Phytochemical Analysis (PCA) 编委,中国生物物理学会代谢组学分会理事,中国生物物理学会生物磁共振专业委员会委员。

主要结合核磁共振技术和液质联用技术开展以下领域研究:(1)代谢组学;(2)结构生物学;(3)复杂混合物核磁共振和液质联用技术定性、定量方法开发。(4)中药药效物质基础与作用机制。

注重理论和技术方法创新,开发了一序列用于生物大分子研究的核磁共振新方法,以及用于代谢组学研究的定性、定量分析方法。拓展新技术、新方法的应用研究,借鉴代谢组学分析策略用于药效物质成分分析,开展疾病相关蛋白质的结构与功能关系研究,发展改良核磁共振方法用于靶向蛋白质的活性分子筛选研究。发表SCI论文近50多篇。

研究组网http://www.hunmrlab.cn/  

二、代表性成果

1.Huan Du, Xiu Gu, Jialuo Chen, Caihong Bai, Xiaohui Duan, Kaifeng Hu*, GIPMA: Global intensity-guided peak matching and alignment for 2D 1H-13C HSQC based metabolomics, Analytical Chemistry, 2023, 95(6):3195-3203

2.Caihong Bai, Suyun Xu, Jingyi Tang, Yuxi Zhang, Jiahui Yang*, Kaifeng Hu*, A ‘shape-orientated’ algorithm employing an adapted Marr wavelet and shape matching index improves the performance of continuous wavelet transform for chromatographic peak detection and quantification, Journal of Chromatography A, 2022, 1673, 463086

3.Xiu Gu, Shu Zhu*, Huan Du, Caihong Bai, Xiaohui Duan, Yiming Li, Kaifeng Hu*, Comprehensive multi-component analysis for authentication and differentiation of 6 Dendrobium species by 2D NMR-based metabolomic profiling, Microchemical Journal, 2022, 176, 107225

4.Tao Huang; Pengyu Chen; Bin Liu; Xing Li; Xinqiao Lv; Kaifeng Hu*; NPid: an automatic approach to rapid identification of known natural products in the crude extract of crabapple based on 2D 1H-13C heteronuclear correlation spectra of the extract mixture, Analytical Chemistry, 2020, 92(16), 10996-11006. 

5.Xing Li; Huan Luo; Tao Huang; Li Xu; Xiaohuo Shi; Kaifeng Hu*; Statistically correlating NMR spectra and LC-MS data to facilitate the identification of individual metabolite in metabolomics mixtures, Analytical and Bioanalytical Chemistry, 2019, 411(7), 1301-1309

6.Tao Huang; Lingling Yu; Xiaofang Ma; Kaifeng Hu*; An adapted isotope dilution 1H-13C heteronuclear single-quantum correlation (ID-HSQC) for rapid and accurate quantification of endogenous and exogenous plasma glucose, Analytical and Bioanalytical Chemistry, 2018, 410(26), 6705-6711.

7.Lingling Yu; Chao Wen; Xing Li; Shiqi Fang; Lichuan Yang; Tony Wang; Kaifeng Hu*; Simultaneous quantification of endogenous and exogenous plasma glucose by isotope dilution LC-MS/MS with indirect MRM of the derivative tag, Analytical and Bioanalytical Chemistry, 2018, 410(7), 2011-2018. 

8.Chao Wen; Dongshan Wang; Xing Li; Tao Huang; Cheng Huang; Kaifeng Hu*; Targeted isolation and identification of bioactive compounds lowering cholesterol in the crude extracts of crabapples using UPLC-DAD-MS-SPE/NMR based on pharmacology-guided PLS-DA, Journal of Pharmaceutical and Biomedical Analysis, 2018, 150,144-151. 

9.Xing Li; Kaifeng Hu*; Quantitative NMR studies of multiple compound mixtures, in: G.A. Webb (Eds.), Annual Reports on NMR Spectroscopy, Academic Press, Elsevier, Oxford, 2017, 90, 85-143. (Invited book chapter)

10.Kaifeng Hu, William M. Westler and John L. Markley*, Two-dimensional concurrent HMQC-COSY as an approach for small molecule chemical shift assignment and compound identification. J. Bio. NMR. 2011, 49(3-4), 291-6. 

11.Roger A. Chylla*, Kaifeng Hu, James J. Ellinger and John L. Markley, Deconvolution of Two-Dimensional NMR by Fast Maximum Likelihood Reconstruction (FMLR): Application to Quantitative Metabolomics. Analytical Chemistry. 2011, 83(12), 4871-80.

12.Kaifeng Hu, Thomas P. Wyche, Tim S. Bugni and John L. Markley*, Selective Quantification by 2D HSQC0 Spectroscopy of Thiocoraline in an Extract from a Sponge-Derived Verrucosispora sp. Journal of Natural Products, 2011, 74(10), 2295-8. 

13.Kaifeng Hu*, James J. Ellinger, Roger A. Chylla and John L. Markley, Measurement of absolute concentrations of individual compounds in metabolite mixtures by gradient-selective time-zero 1H-13C HSQC (gsHSQC0) with two concentration references and fast maximum likelihood reconstruction analysis. Analytical Chemistry, 2011, 83(24), 9352-60.

14.Kaifeng Hu, William M. Westler and John L. Markley*, Simultaneous quantification and identification of individual chemicals in metabolite mixtures by two-dimensional extrapolated time-zero 1H-13C HSQC (HSQC0). J. Am. Chem. Soc., 2011, 133(6), 1662-5.

 

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