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中药制剂学

李小芳

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一、个人简介

李小芳博士、教授、博士研究生导师、博士后合作导师,成都中医药大学优势特色学科药剂学学带头人四川省高等学校“课程思政”示范课《中药提取工艺学》教学团队负责人

为国家中医药考试命审题专家、国家自然科学基金委同行评议专家、国家卫健委医药卫生科技发展中心科研项目评审专家、教育部学位中心评审专家、四川省院士(专家)工作站专家、四川省科技计划项目评审专家、四川省科技成果奖励评审专家、四川省药品注册现场核查专家、四川省医疗保障专家库专家、北京市自然科学基金评审专家、河北省科技计划项目评审专家。尚任中华中医药学会中药制剂分会常务委员、世界中医药学会联合会道地药材多维评价专业委员会常务理事、成都市药学会第八届药剂专业委员会副主任委员等学术职务。

长于中药新药、中药制剂关键技术及中药新型递药系统等领域的研究。作为负责人和主研人员承担了国家“十五”科技攻关项目、国家自然科学基金项目、科技部863项目、国家“十一五”科技支撑计划以及部省级、厅局级课题共40余项;作为主研参与并取得具有代表性的科研成果有藿香正气液的研制、太极通天液的研制,均获生产批文,已上市。“藿香正气口服液的制备方法”于1997年获中国专利发明金奖,为国内首次获此殊荣的中药产品。

   公开发表学术论文200余篇, SCI论文50余篇,其中多篇入选ESI药理学与毒理学学科高水平论文及高被引论文。

主编、副主编《中药药剂学》、《中药药剂学实验》双语教材、《药剂学》、《中药提取工艺学》、《中药制药工艺学》等国家规划教材10余部。以第一发明人申请国家发明专利12项,已授权8项;获四川省及成都市科技进步奖6项。

已为国家培养硕、博士研究生90余名。

三、代表性成果

1.Chen, Huijuan; Deng, Mao; Xie, Long; Liu, Kai; Zhang, Xumin; Li, Xiaofang. Preparation and characterization of quercetin nanosuspensions using gypenosides as novel stabilizers. JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 2022, 67.

2.Deng, Mao; Chen, Huijuan; Xie, Long; Liu, Kai; Zhang, Xumin; Li, Xiaofang. Tea saponins as natural emulsifiers and cryoprotectants to prepare silymarin nanoemulsion. LWT-FOOD SCIENCE AND TECHNOLOGY. 2022, 156.

3.Zheng, Yu; Zhao, Yuxin; Bai, Mengting; Gu, Huan; Li Xiaofang. Metal-organic frameworks as a therapeutic strategy for lung diseases. J Mater Chem B. 2022, 10(30):5666-5695.

4.Lu, Jing; Xie, Long; Wu, Anxin; Wang, Xian; Liang, Youdan; Dai, Xiaolin; Cao, Yi; Li, Xiaofang. Delivery of silybin using a zein-pullulan nanocomplex: Fabrication, characterization, in vitro release properties and antioxidant capacity. COLLOIDS AND SURFACES B-BIOINTERFACES. 2022, 217.

5.谢青璇, 李小芳, 谢龙,王娴,曹怡,梁由单. Box-Behnken效应面法优化大黄素/小檗碱-壳聚糖双载药纳米粒的处方工艺研究[J]. 中草药, 2021, 52(6):9.

6.龙家英,李小芳,王娴,邓茂,古环,谢龙,陈慧娟,代小琳.茶皂素用于稳定橙皮苷纳米混悬剂及其机制研究[J].药学学报. 2021,56(11).

7.Cao Yi, Xie Long, Liu Kai, et al. The antihypertensive potential of flavonoids from Chinese Herbal Medicine: A review[J]. Pharmacological Research. 2021,174.

8.Liu Kai, Zhang Xumin, Xie Long, et al. Lupeol and its derivatives as anticancer and anti-inflammatory agents: molecular mechanisms and therapeutic efficacy[J]. Pharmacological Research, 2021,164.

9.Jiawen Song, Jiaying Long, Long Xie, Qiang Sun, Linlin Zhang, Huijuan Chen, Mao Deng, Xiaofang Li, Solubilization and changes of physicochemical properties of baicalin by nano sponge, and toxicity of zebrafish liver, Journal of Drug Delivery Science and Technology. 2020, 60.

10.Jiaying Long, Jiawen Song, Xumin Zhang, Mao Deng, Long Xie, Linlin Zhang, Xiaofang Li. Tea saponins as natural stabilizers for the production of hesperidin nanosuspensions [J]. International Journal of Pharmaceutics. 2020, 583.

11.Chengying Shen, Junjun Zhu, Jiawen Song, Jing Wang, Baode Shen, Hailong Yuan, Xiaofang Li. Formulation of Pluronic F127/TPGS Mixed Micelles toImprove the Oral Absorption of Glycyrrhizic Acid. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 2020, 46(7):1100-1107.

12. Ren, Guilin; Zhong, Yu; Ke, Gang; Liu, Xiaoli; Li, Huiting; Li, Xiaofang; Zheng, Qin; Yang, Ming. The Mechanism of Compound Anshen Essential Oil in the Treatment of Insomnia Was Examined by Network Pharmacology[J]. Evidence -Based Complementary and Alternative Medicine. 2019, 2019.

13. Zhao, Tiantian; Tang, Hailong; Xie, Long; Zheng, Yu; Ma, Zubing; Sun, Qiang; Li, Xiaofang. Scutellaria baicalensis Georgi. (Lamiaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology[J]. Journal of Pharmacy and Pharmacology. 2019,71(9):1353–1369.

14.Yu Zheng, Lan Bai, Yanping Zhou, Rongsheng Tong, Minghui Zeng, Xiaofang Li, Jianyou Shi. Polysaccharides from Chinese herbal medicine for anti-diabetes recent advances[J]. International Journal of Biological Macromolecules, 2019, 121: 1240–1253.

15.Chengli Ling, Jianming Liang, Chun Zhang, Ruixiang Li, Qianqian Mou, Jin Qin, Xiaofang Li, Jianxin Wang. Synergistic Effects of Salvianolic Acid B and Puerarin on Cerebral Ischemia Reperfusion Injury[J]. Molecules 2018, 23(3):564.

 

 

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