1、个人简介
刘芳，副教授，中药学博士后，硕士生导师，澳大利亚昆士兰大学访问学者，现代中药产业学院中药注册与知识产权保护产教中心主任，入选四川省中医药管理局学术与技术带头人后备人选。研究方向：①中药新制剂与新剂型研究；②中药/食品与人工智能AI结合，以及道地中药厚朴产地加工发汗炮制作用原理研究；③中药大健康产品研发与转化，如开发出中药丹参面膜获得授权专利，并实现成果转化。
主持国家自然科学基金青年基金、中国博士后科学基金、省科技厅、省社科联等各级各类科研课题10余项，获得教育部科学技术进步奖（推广类）二等奖2项，四川省学位与研究生教育管理研究优秀成果奖1项，授权专利成果转化1项，指导学生参加第十六届全国大学术药苑论坛获得创新成果三等奖、第十一届全国大学生医学创新大赛暨“一带一路”国际竞赛省赛一等奖（全国三等奖）、四川省国际“互联网+”大学生创新创业大赛获得银奖等。兼任中华中医药学会中药制剂专委会委员，四川省适宜技术研究会常务理事，参编《中药药剂学实验》双语等教材3部，论著4部。培养的研究生雷**2026年成为省级优秀毕业生。
联系邮箱：297933995@qq.com Tel：15828345121/18980649295
二、代表性成果（可含承担项目、发表论文、论著、获奖等）
1. 近年以通讯作者或第一作者发表的部分论文
[1]Ruiyuan Zhang, Yicheng Lei, Fang Liu, Zhenqing Meng, Yao Song, Lin Li, Haiyan Huang, Yong Luo and Chaomei Fu. Application of chemometrics based on digital images and deep learning for analyzing quality of Magnolia officinalis cortex during sweating processing. Journal of Pharmaceutical Analysis, 2026: 101678.（中科院一区top期刊, IF=11.2）
[2]Zhenqing Meng, Lin Li, Chunyan Liu, Ruiyuan Zhang, Yicheng Lei, Huiwen Pang, Chen Chen, Li Li, Fang Liu. Digital image analysis coupled with machine learning for rapid assessment of coffee of various roasting degrees and prediction of caffeine and chlorogenic acid content [J]. Food Control,2026.（中科院一区top期刊）
[3]Ruiyuan Zhang, Lin Li, Yao Song, Yicheng Lei, Zhenqing Meng, Yile Li, Xiaoyu Yan, Huiwen Pang, Chen Chen, Chaomei Fu, Fang Liu. Dynamic changes in chemical components during sweating processing of Magnolia officinalis cortex based on UPLC-Q-TOF-MS metabolomics and MALDI-MSI. Talanta, 2026: 129584.（一区top期刊）
[4]Ruiyuan Zhang, Li Yang, Lin Li, Haiyan Huang, Yao Song, Yicheng Lei, Yuan Hu*, Shiyin Chen*, Fang Liu*. Advance in the characteristics, bioactivities, and drug delivery application of chitosan and its derivatives for osteoarthritis: A review[J].Carbohydrate Polymers,2026,373:124570（中科院一区top期刊）
[5]Yicheng Lei, Ruiyuan Zhang, Fang Liu⁎,Zhenqing Meng, Yao Song, Chaomei Fu,Ying Liang⁎,Rapid discriminate and determination of chemical constituents of Canarii Fructus (Chinese olive) and Chebulae Fructus Immaturus using digital image-based color histograms and chemometrics[J].Talanta, 2026（一区top期刊）
[6]Ruiyuan Zhang, Lin Li, Yao Song, Yicheng Lei, Zhenqing Meng, Yile Li, Xiaoyu Yan, Huiwen Pang, Chen Chen, Chaomei Fu, Fang Liu*. Dynamic changes in chemical components during sweating processing of Magnolia officinalis cortex based on UPLC-Q-TOF-MS metabolomics and MALDI-MSI[J]. Talanta. 2026,305:129584.（中科院一区top期刊）
[7]Yao Chen, Lin Li, Ruiyuan Zhang, Fang Liu*. A review of Lycium barbarum polysaccharides: Structural characteristics,antitumor molecular mechanism and transformation application..International Journal of Biological Macromolecules, 2026.
[8]Luping Yang, Yunjie Hu, Hongdan Deng, Yan Li, Ruiyuan Zhang, Qian Zhang, Li Yang, Huiwen Pang, Fang Liu*, Chaomei Fu*. Water-soluble polysaccharides from Torreya grandis nuts: Structural characterization and anti-inflammatory activity[J]. International Journal of Biological Macromolecules, 2025:138935.（中科院一区top期刊）
[9]Qian Zhang, Hongdan Deng, Ruifeng Luo, Hu Qi, Yicheng Lei, Luping Yang, Huiwen Pang, Chaomei Fu, Fang Liu*.Oral food-derived whey protein isolate-Tremella fuciformis polysaccharides pickering emulsions with adhesive ability to delivery magnolol for targeted treatment of ulcerative colitis[J].International Journal of Biological Macromolecules, 2024:135585.（中科院一区top期刊）
[10]Ruiyuan Zhang , qian Zhang, Shun Zhu, Biyang Liu, Fang Liu*, Yao Xu*. Mulberry leaf (Morus alba L.): A review of its potential influences in mechanisms of action on metabolic diseases[J], Pharmacology Research,2022, 175:106029（中科院一区top期刊）（高被引论文）
[11]Lin Li, Ruiyuan Zhang, Yichen Hu, Hongdan Deng, Xu Pei, Fang Liu*, Chen
Chen*.Impact of oat (Avena sativa L.) on metabolic syndrome and potential physiological mechanisms of action [J]. Journal of Agricultural and Food Chemistry,2023（中科院一区top期刊）
[12]Ruiyuan Zhang, Fang Liu*, Qian Zhang, Luping Yang, Xinlian Hou, Taoming Du, Jie Fan, Huiling Hu, Hongdan Deng, Li Hao, Li Guo*, Chaomei Fu. Intra-articular delivery system of methotrexate for rheumatoid arthritis therapy: An in-suit thermosensitive comprehensive gel of polysaccharide from Aconitum carmichaelii Debx [J]. International Journal of Biological Macromolecules,2023,244:124822.（中科院一区top期刊）
[13]Yicheng Lei, Ruiyuan Zhang, Yan Li, Huiwen Pang, Qiang Fu, Chen Chen, Fang Liu*.Pueraria Radix and its major constituents against metabolic diseases:Pharmacological mechanisms and potential applications,Phytotherapy Research,2025(二区top期刊)
[14]Ruiyuan Zhang, Caijia Shen, Yicheng Lei, Yao Song, Lin Li, Huiwen Pang, Chen Chen, Yichen Hu, Chaomei Fu, Fang Liu. Cinnamon (Cinnamomum) as a Food-Medicine Homologue: A Review of Pharmacological Mechanisms and Potential Applications in Metabolic Diseases. Food Reviews International,2025.
[15]Yiwen Bao, Ruiyuan Zhang, Xinyi Jiang, Fang Liu*, Yao He*, Huiling Hu, Xinlian Hou, Li Hao.Detoxification mechanisms of ginseng to aconite: a review[J],Journal of Ethnopharmacology,2023
[16]Shun Zhu, Fang Liu*, Ruiyuan Zhang, Zongxiang Xiong, Qian Zhang, Li Hao, Shiyin Chen*. Neuroprotective Potency of Neolignans in Magnolia officinalis Cortex Against Brain Disorders[J]. Frontier in Pharmacology,2022,13:857449
[17]Shaoyang Liu, Ruiyuan Zhang, Xing Zhang, Shun Zhu, Siyu Liu, JueYang, Zhiping Li, Tianhui Gao*, Fang Liu*, Hu Huiling.The Invasive Species Reynoutria japonica Houtt. as a Promising Natural Agent for Cardiovascular and Digestive System Illness[J], Frontier in Pharmacology,2022, 13:863707
[18]Chunlei Wei , Jing Qiu, Yuyi Wu, Ziqiang Chen, Ziwei Yu, Zecheng Huang, Ke Yang, Huiling Hu*, Fang Liu*. Promising traditional Chinese medicine for the treatment of cholestatic liver disease process （cholestasis, hepatitis, liver fibrosis, liver cirrhosis）[J],Journal of Ethnopharmacology,2022,297
[19]Xiao Wang, Shu Fu, Chen Zhang, Xin Nie, Wan Liao, Ming Zhao, Fang Liu*. Gastroprotective Effect of Ethanol Extracts from Bark of Magnolia officinalis on Ethanol-Induced Gastric Mucosal Damage in Rats[J].Biomed Research International, 2021, 2021:6688414
[20]Xiao Wang, Chen Zhang, Mingyue Zheng,Fei Gao, Jinming Zhang*, Fang Liu*.Metabolomics Analysis of L-Arginine Induced Gastrointestinal Motility Disorder in Rats Using UPLC-MS After Magnolol Treatment[J], Frontiers in pharmacology, 2019, 10: 183.
[21]宋姚,张芮苑,刘芳*.基于HPLC指纹图谱与颜色RGB的厚朴发汗前后成分与颜色变化相关性研究[J].中草药,2025,56(16):5772-5781.
[22]张倩,刘芳*,张芮苑,邓鸿丹,杨璐萍,任虹.厚朴挥发油纳米乳凝胶的制备及其对溃疡性结肠炎小鼠的药效评价[J].中草药,2024,55(3):746-756.
[23]张芮苑,宋姚,李琳,柏灵,宋姚,李琳,宋姚,雷以珵,蒙振清,傅超美*,李婷婷,刘芳*,罗霄*.基于电子鼻和GC-MS分析厚朴“发汗”炮制过程气味差异及其物质基础的动态变化[J/OL].2026,中国中药杂志,1-15.
2. 代表性课题
国家自然科学基金委员会，青年基金，81603300，基于“组分-效用-靶点”研究厚朴“发汗”增味减燥作用机制，主持（国家级）
国家自然科学基金委员会，面上项目，81473354，基于体内分布及机体答应部位差异性的川木香煨制和归经趋向，参加（国家级）
中国博士后基金，面上项目，2020M673569XB，基于5-HT信号系统研究川产道地药材厚朴产地加工“发汗”增效作用机制，主持（省部级）
四川省科技厅，省自然科学基金面上项目，2026NSFSC0621，川产道地药材“紫油厚朴”优质品质形成过程木脂素类成分变化规律及品质评价研究，主持（省部级）
四川省科技厅，省自然科学基金面上项目，2023NSFSC0661 ，基于“成分-药性-药效”关联的“紫油厚朴”产地加工发汗作用机理研究，主持（省部级）
四川省科技厅，应用基础研究计划，20YYJC0655，基于“药-证-效”关键质量属性传递的川产道地中药厚朴质控体系的研究，主持（省部级）
四川省科技厅，苗子工程项目，基于“构效信息-体内表征”模式研究厚朴产地“发汗”的机制，主持（省部级）
四川省社会科学联合会，健康中国战略下绿色食品植物应用指南，主持（省部级）
四川省社科联项目，中医药文化知多少-推动实施健康优先发展战略社科科普读本，省部级，KP24，2025.1-2025.6，主持（省部级）
四川省教育厅，重点项目，基于“谱效模型”研究厚朴产地加工“发汗”作用机制，主持
四川省中医药管理局，基于和厚朴酚纳米温敏凝胶的奶牛乳腺炎“替抗” 中兽药开发研究，2025.9-2027.8，主持
成都市科技局课题，基于附子多糖为载体的抗类风湿性关节炎原为温敏水凝胶的研究，2022.8-2023.8，主持
成都市科技局，现代农业视角下艾叶-花椒特色外用膏的开发及应用示范，2025.8-2026.8，主持
